pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ CAS #: 9004-34-6 ( Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. The figure below illustrates the structural organisation of cellulose within plants. : 1. <> Avicel PC 611 (FMC Biopolymer) Supplied by. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. No. Avicel PH-101. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. PDF (4.11 mb) Footer menu 1. It works as a moisture sponge and permits the controlled growth of spheroids. Learn about FMC's differentiated biologically-based crop solutions. All rights reserved. Some substance identifiers may have been claimed confidential, or may . Request media, explore upcoming events and read our latest updates. The Microcrystalline Cellulose monograph will be incorporated into and become official with the Second Supplement to . FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. 4 0 obj . To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. Chemical Formula: (C6H10O5)n 1.4. Manufacturer: FMC BioPolymer. G2W4de=u183KGH{ vQ#4:1\wc Avicel PC 611 (FMC Biopolymer) . X\o^ Looking for FMC'searnings news? >> MSDS Ref. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. No. ( Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. 2 0 obj Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. Catalog Number 102331. Watch Now. Are you sure you want to delete your template? Origin(s): Plant/Botanical. endobj An agricultural sciences company. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER endobj MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Report Category. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Product and Company Identification . . Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. 5 0 obj The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. B;vLZpHU%ChUyD+[ Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Protect them from sunshine or rain. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. In 1964 FMC, Corporation . Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Trademarks: Avicel PH-102. Well-recognized product that can do it all. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Micro Crystalline Cellulose. % XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM CAS 9004-34-6, pH 5 - 7.5. gac74 [#B6`Wnw7 The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. q9;v80q>jZ Performing this action will revert the following features to their default settings: Hooray! In large quantities it provides dietary bulk and may lead to a laxative effect. (&E. SUBSTANCE IDENTIFICATION 1.1. 9,LL!z Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. endobj CAS #: 9004-34-6 1.6. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. It is a white, free-flowing powder. Explore how you can develop your career and bring your creative ideas to life at IFF. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. However, it yields non-digestible fibre. The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. INCI. stream Safety Data Sheet for Cellulose microcrystalline 102331. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. A., and Smith, P. A. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Find answers in our support articles. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. 130. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. };khd5x=fr Gloves, eye protection and a dust mask should be used. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Biologicals by FMC. All Rights Reserved. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. . Explore how we work and why we apply science and creativity for a better world to everything we do. xv}O2' H~KEe9>G/,:9\i >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[ Material safety data sheet - FMC Corporation. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109.

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